One other thread about Route 66 got me thinking about this, because there's a wigwam hotel that I always thought looked so quirky and unique. Another place I stayed was the Madonna Inn, which is just off the Pacific Coast Highway. All the rooms are decked out in different themes and it's crazy but super cool. The room I had was set up all like a cave - so bizarre but it sure was memorable. Do you know of any other weird or wacky hotels in the US?